Air quality changes in Shijiazhuang during COVID-19 outbreak

[Background] The coronavirus disease 2019 (COVID-19) was first detected in December 2019. To combat the disease, a series of strict measures were adopted across the country, which led of improved air quality. This provides an opportunity to discuss the impact of human activities on air quality. [Objective] This study investigates the air quality changes in Shijiazhuang, and analyzes the impacts of epidemic prevention and control measures on air quality, so as to provide reference and ideas for further improving air quality and prevention and control measures. [Methods] The air quality data were collected online from https://www.zq12369.com/ and https://aqicn.org/city/shijiazhuang/cn/. Comparisons in air quality index (AQI) and the concentrations of air pollutants (PM2.5, PM10, SO2, CO, NO2, and O3) were made between the period from December 2019 to June 2020 (reference) and the same period from 2016 to 2019 by t-test and chi-square test. [Results] The daily average AQI dropped by 25.38% in Shijiazhuang during the COVID-19 prevention and control compared with the some period from 2016 to 2019 (t=6.28, P < 0.05). The proportions of pollution days during the COVID-19 outbreak in Shijiazhuang were PM2.5 (44.56%), O3 (31.09%), PM10 (23.83%), and NO2 (2.59%) successively, the pollution days of PM10 decreased significantly (chi2=3.86, P < 0.05) compared with 2016-2019, but during traffic lockdown the numbers of pollution days of PM2.5 and in the mid stage of prevention the number of pollution days of O3 increased (P < 0.05). Compared with the control period, the concentrations of the six air pollutants decreased to varying degrees (P < 0.05), especially SO2 dropped by 55.36%. [Conclusion] The measures taken for COVID-19 control and prevention have reduced the pollution sources and emissions, which resulted in better general air quality of Shijiazhuang City, but have aggravated the pollution of O3 and other pollutants. It is necessary to further explore the causes for the aggravation of O3 pollution in order to formulate reasonable air quality control strategies.Copyright © 2021, Shanghai Municipal Center for Disease Control and Prevention. All rights reserved.

Determining the Effect of KmtR Mutants, E101Q, H102Q, and H111Q on the Metal Binding Affinities

Mycobacterium tuberculosis is the second leading infectious killer after COVID-19. The bacteria utilizes several metal transport systems to help it survive in the host.With an increase in the number of multiresistant, extensively resistant and totally drug-resistant strains, the development of new therapeutic strategies that target other essential pathways in the bacteria is critical. The bacteria contain several metal transport systems which are necessary for its survival. Additionally, the bacteria has two metalloregulators that are associated with nickel and cobalt export, NmtR and KmtR. The focus of this research is on KmtR, which represses the expression of the genes, cdf (which encodes the export protein) and kmtR. The goal of our research is to identify the residues that are responsible for binding the cognate metals, nickel and cobalt, as well as the noncognate metal, zinc, to KmtR. Mutagenesis studies coupled with metal binding experiments will be used to determine how KmtR binds these metals. The E101Q, H102Q, and H111Q mutants, among others, have been made, expressed, and purified in our lab. Data obtained from Isothermal Titration Calorimetry determined that all three mutant proteins bind cobalt with nanomolar affinities and the H111Q mutant KmtR proteins binds cobalt an order of magnitude weaker than the other two mutant proteins. Research reported as supported fully by the RI Institutional Development Award (IDeA) Network for Biomedical Research Excellence (RI-INBRE) from the National Institute of General Medical Sciences of the National Institutes of Health under grant #P20GM103430.Copyright © 2023 The American Society for Biochemistry and Molecular Biology, Inc.

Structural and Computational Studies of Cobalt(II) and Copper(II) Complexes with Aromatic Heterocyclic Ligand

Two coordination complexes, a cobalt(II) complex tris(1,10-phenanthroline)-cobalt perchlorate hydrate, [Co(phen)3]·(ClO4)2·H2O(1), and a copper(II) complex tris(1,10-phenanthroline)-copper perchlorate 4-bromo-2-{[(naphthalene-1-yl)imino]methyl}phenol hydrate, [Cu(phen)3]·(ClO4)2·HL·[O] (2), [where, phen = 1,10-phenathroline as aromatic heterocyclic ligand, HL = 4-bromo-2-((Z)-(naphthalene-4-ylimino) methyl) phenol] have been synthesized and structurally characterized. Single crystal X-ray analysis of both complexes has revealed the presence of a distorted octahedral geometry around cobalt(II) and copper(II) ions. density functional theory (DFT)-based quantum chemical calculations were performed on the cationic complex [Co(phen)3]2+ and copper(II) complex [Cu(phen)3]2+ to get the structure property relationship. Hirshfeld surface and 2-D fingerprint plots have been explored in the crystal structure of both the metal complexes. To find potential SARS-CoV-2 drug candidates, both the complexes were subjected to molecular docking calculations with SARS-CoV-2 virus (PDB ID: 7BQY and 7C2Q). We have found stable docked structures where docked metal chelates could readily bound to the SARS-CoV-2 Mpro. The molecular docking calculations of the complex (1) into the 7C2Q-main protease of SARS-CoV-2 virus revealed the binding energy of −9.4 kcal/mol with a good inhibition constant of 1.834 µM, while complex (2) exhibited the binding energy of −9.0 kcal/mol, and the inhibition constant of 1.365 µM at the inhibition binding site of receptor protein. Overall, our in silico studies explored the potential role of cobalt(II) complex (1), and copper(II) complex (2) complex as the viable and alternative therapeutic solution for SARS-CoV-2.

The Paradox of Green Growth: Challenges and Opportunities in Decarbonizing the Lithium-Ion Supply Chain

Global decarbonization is a megatrend destined to impact multiple sectors of the economy. The commodity sector in particular looks set to benefit, given the acute need for raw materials to feed the energy transition. This global transition will take decades and while an "all of the above” energy policy will be necessary, the lithium-ion battery promises to play a central role in the decarbonization of the transportation and grid scale energy storage sectors. With lithium-ion battery costs falling steadily since the early 1990s, many believe that the technology promises to become even more ubiquitous, helping to electrify the global economy. Recent exogenous shocks such as the US-China trade war, COVID-19, and the Russian invasion of Ukraine have underlined the fragility of global energy supply chains and the need for a resilient global energy infrastructure. While solutions to the exogenous shocks seem straightforward, there is an increasingly evident paradox. To achieve significant decarbonization and electrification goals, more, not fewer, battery raw materials will be required and the energy used to produce these materials will almost certainly originate from fossil fuels, possibly slowing the decline of the carbon intensity of industry. Innovation along the supply chain is the only realistic way to achieve large-scale decarbonization. This will require R&D, necessitating a coordinated response between the public and private sector as supply chains evolve. This chapter looks at the geopolitical, economic, technological, and legislative challenges and opportunities that green growth presents in the lithium-ion battery ecosystem as the industry embarks on a rapid growth phase. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Coronavirus-like Core-Shell-Structured Co@C for Hydrogen Evolution via Hydrolysis of Sodium Borohydride.

Constructing a reliable and robust cobalt-based catalyst for hydrogen evolution via hydrolysis of sodium borohydride is appealing but challenging due to the deactivation caused by the metal leaching and re-oxidization of metallic cobalt. A unique core-shell-structured coronavirus-like Co@C microsphere was prepared via pyrolysis of Co-MOF. This special Co@C had a microporous carbon coating to retain the reduced state of cobalt and resist the metal leaching. Furthermore, several nano-bumps grown discretely on the surface afforded enriched active centers. Applied in the pyrolysis of NaBH4, the Co@C-650, carbonized at 650 °C, exhibited the best activity and reliable recyclability. This comparable performance is ascribed to the increased metallic active sites and robust stability.

Supply chain risks of critical metals: Sources, propagation, and responses

In the era of globalization, industries of critical metals are organized through the global supply chain. However, the global supply chains have been disrupted since 2020 by the outbreak of COVID-19 and a series of geopolitical crises. To better address the supply chain challenges of critical metals, a review is needed about the sources, propagation, and responses of the supply chain risks. Firstly, this review provides an overview about the research progress in identifying the risk sources and assessing the risks and then proposes a new supply chain framework, categorizing relevant risk factors into upstream risks, middle-stream risks, downstream risks, and general risks, for risk analysis of critical metals. Secondly, this review offers a comprehensive understanding about how the risks propagate horizontally and vertically. Finally, responses such as supply diversification, stockpiling, material substitution, recycling and circular economy strategy, price volatility hedging, and supply chain traceability are reviewed. This survey features the supply chain perspective, overviews on network-based studies, and affirms the urgency and need for further studies on supply chain risks and resilience, which may contribute to a smooth clean energy transition.

A green closed-loop process for selective recycling of lithium from spent lithium-ion batteries

As the economy started to recover from the COVID pandemic, the price of Li2CO3 skyrocketed to its highest. This situation has aggravated concerns about the supply chain for lithium-ion batteries (LIBs). Recycling spent LIBs is a potential solution to alleviate the bottleneck of the supply chain and prevent environmental pollution, and has attracted lots of attention. However, lithium recycling is generally disregarded because of the complex recycling process and its low recycling efficiency. Here, in this work we developed a sustainable lithium recovery process, which can selectively leach and recover lithium with formic acid before recycling valuable metals. With the reported method, lithium can be 99.8% recovered from layered oxide cathode materials with 99.994% purity. In addition, this lithium recovery process is affordable, compared to the typical hydrometallurgical process, by saving 11.15% per kilogram of spent LIBs. Therefore, this research provided a new solution to eliminating the effects of lithium ions on valuable metal separation and the co-precipitation reaction and precluding the influence of other metal ions on lithium recovery. This simplified lithium recovery process provides new opportunities for sustainable recycling of LIBs and economical restoration of the lithium supply chain.

Ni-Co Bearing Laterites from Halmahera Island (Indonesia)

Eastern Indonesia, including the island of Halmahera, is a region with a high mineral potential, particularly Ni-Co, Au-Cu, and Ag ores, which are a globally important and critical source of raw materials (CRMs). The research was conducted within the framework of scientific cooperation between the Faculty of Geology, University of Warsaw (Poland), and PT Halmahera Resources Percasa Ltd. (Jakarta, Indonesia) Between the years of 2009 and 2011, 42 boreholes were drilled using an impact system (up to 15 m below surface) and 3 test pits (up to 8 m below surface). The presence of a laterite deposit containing Ni-Co mineralization was identified on the license area. The resources estimated in accordance with JORC Code, with a cut-off grade Ni ≥ 0.5%, equaling 185,510 t Ni and 17,747 t Co, with the stock of raw material amounting to 14.8 million t and with an average content of 1.00% Ni and 0.13% Co. The ore in the deposit has mixed character. To date, studies have shown the dominance of oxide ore, but saprolite composed of magnesium silicates was also identified in significant amount. The Ni mineralization in oxide ore (limonite) is bound to goethite and manganese minerals, while in the case of silicate (saprolite) ore, it occurs locally in the form of veins as well as zonally in the weathered serpentinites. Cobalt mineralization is almost entirely related to the Mn minerals that occur in the lower oxide zone. It has been found that both serpentinites and harzburgites (and possibly locally lherzolite) are the parent rocks for laterite deposit.

Theoretical Description for Anti-COVID-19 Drug Molnupiravir Electrochemical Determination over the Poly-((1,2,4-triazole)-co-(squaraine dye)) Composite with Cobalt (III) Oxyhydroxide

The possibility of electrochemical determination of molnupiravir has been theoretically evaluated for the first time. The molnupiravir electrochemical oxidation over the poly((1,2,4-triazole)-co-(squaraine dye)) composite with cobalt (III) oxyhydroxide has been theoretically evaluated. The correspondent mathematical model analysis has shown that the composite is an efficient electrode modifier for molnupiravir electrochemical determination. As for the oscillatory behavior is more probable than for the simplest case, and its probability will be higher in alkaline media than in neutral.

Allergic contact dermatitis caused by elastic bands from FFP2 mask

Background: A 29-year-old woman, with personal history of atopy, presented with face and neck dermatitis lasting 6 months. During the past year, she worked as a nurse in a COVID-19-dedicated ward. The dermatitis had developed since she started using FFP2 masks. She referred using three FFP2 masks, with similar symptoms: 3 M© 9320+, Halyard© Fluidshield N95 and PM 2.5©. She also mentioned history of contact-hypersensitivity reactions to metals, green clothes and leather shoes for several years. Physical examination exhibited erythematous plaques distributed along the contact area of the elastic bands of the FFP2 masks. Patch tests revealed delayed hypersensitivity to the elastic bands 3 M© 9320+ and PM 2.5© (++), mercapto mix (++), 2-mercaptobenzothiazole (MBT) (++), 2-(4-morpholinylmercapto)benzothiazol (MOR) (++), N-cyclohexyl-2-benzothiazolesulfenamide (++), textile dye mix Mx-30 (++), disperse yellow 3 (++), disperse blue 106 (+), potassium dichromate (+), cobalt dichloride (+) and nickel sulfate hexahydrate (+). A latex skin prick test was negative. Allergic contact dermatitis (ACD) caused by elastic bands of FFP2 masks (3 M© 9320+ and PM 2.5 ©) was diagnosed. She was prescribed methylprednisolone aceponate 0.1% cream bid during five days and masks were changed to a type with cotton cloth bands, with resolution of the complaints. ACD to FFP2 masks components in health care workers can be severe, given the prolonged and continuous contact with the source of allergens. The rubber additives thiurams and dithiocarbamates are the main allergen groups involved in ACD to rubber bands in FFP2 masks. This seems to be the first report caused by mercaptobenzothiazole.

42nd International Congress of the European Association of Poisons Centres and Clinical Toxicologists

The proceedings contain 209 papers. The topics discussed include: an illicit drug early warning system utilizing comprehensive toxicological analysis of emergency department presentations in Victoria, Australia;4-fluoroamphetamine (4-FA) intoxication results in exaggerated blood pressure effects compared to 3,4-methylenedioxymethamphetamine (MDMA) and amphetamine: a retrospective analysis;single nucleotide polymorphisms of mu opioid receptor gene OPRM1 in emergency department patients with acute opioid overdose;ketamine in acute recreational poisonings in the Balearic Islands;the neuro-respiratory effects of pregabalin and the potential deleterious effects of its combination with diazepam or morphine ? a rat investigation;cobaltism from metal-on-metal (MoM) hip implants: how to manage and treat with acetylcysteine;analytically-confirmed polydrug use is more common in drug misuse patients attending emergency departments in Scotland compared with those in England and Wales;and it is not always COVID-19: a case of respiratory failure from lung damage associated with electronic cigarettes (EVALI).

COVID-19: One Year Later

Whether through creative uses of cell phone technology, makeshift lab equipment, or the use of virtual laboratory and virtual field trip events, our students were able to experience science in new and powerful ways. Science teachers adapted and shared their ideas, using social media groups such as Facebook's "NGSS Chemistry Teachers," "NGSS Biology Teachers," and other science teaching groups. All COVID-19 vaccines are free from metals such as iron, nickel, cobalt, lithium, and rare earth alloys, as well as any manufactured products such as microelectronics, electrodes, carbon nanotubes, and nanowire semiconductors.

Environmental Sustainability and Supply Resilience of Cobalt

Cobalt (Co) is an essential metal for the development of energy-transition technologies, decarbonising transportation, achieving several sustainable development goals, and facilitating a future net zero transition. However, the supply of Co is prone to severe fluctuation, disruption, and price instabilities. This review aims to identify the future evolution of Co supply through technologically resilient and environmentally sustainable pathways. The work shows that advances in both primary and secondary sources, Co mining methods and recycling systems are yet to be fully optimised. Moreover, responsible sourcing from both large mines and small artisanal mines will be necessary for a resilient Co supply. Regulatory approaches may increase transparency, support local mining communities, and improve secondary Co recovery. Novel Co supply options, such as deep-sea mining and bio-mining of tailings, are associated with major techno-economic and environmental issues. However, a circular economy, keeping Co in the economic loop for as long as possible, is yet to be optimised at both regional and global scales. To achieve environmental sustainability of Co, economic incentives, regulatory push, and improved public perception are required to drive product innovation and design for circularity. Although the complexity of Co recycling, due to lack of standardisation of design and chemistry in batteries, is an impediment, a sustainable net zero transition using Co will only be possible if a reliable primary supply and a circular secondary supply are established.

Highly efficient textile supercapacitors made with face masks waste and thermoelectric Ca3Co4O9-δ oxide

We studied the electrochemical performance of solid state supercapacitors (SCs) made with surgical face mask (FM) waste and blister packs recycled from paracetamol packaging. The Ca3Co4O9-δ (CaCo) oxide was also deposited on the SC electrodes to store charge by redox reactions. The CaCo microparticles had a plate-like morphology and had sizes in the range of 1–4 µm. They also presented a monoclinic phase according to the analysis by the X-ray diffraction. The electrochemical characterization of the face mask-based SCs was carried out and found maximum capacitance/energy density values of 1706.2 F g−1/208.4 Wh kg−1 and 816.8 F g−1/99.7 Wh kg−1 for the SCs made with and without CaCo, respectively. Thus, incorporating the CaCo into the SCs improved the energy density and capacitance by ≈108%. The best device made with CaCo also presented a moderate capacitance retention of 82.1% after 1500 cycles of charge/discharge and long discharge times of at least 10 h (at a maximum output voltage of 0.54 V). Additionally, the devices were subjected to pressing conditions by putting on them weights of 0.1–0.5 Kg and their capacitance retention was only reduced by 0.7–1.5%. The analysis by XPS, Absorbance and Raman measurements pointed out that the SCs made with CaCo presented extra redox species of Co2+/Co3+ and oxygen vacancies on their electrodes;therefore, they could store charge by redox reactions. Hence, the results presented here revealed that highly efficient SCs are possible to make from medical waste and this could help to decrease the environmental contamination by plastic residuals. © 2021 Elsevier Ltd

Development and Assessment of an Inexpensive Smartphone-Based Respiratory Droplet Simulation Model.

Background. Droplet simulation often requires expensive and inaccessible equipment. Herein, we develop and assess a low-cost droplet simulation model using easily accessible materials, open-source software, and a smartphone-based cobalt blue light. Methods. The simulation model was developed using commercial-grade materials and fluorescein dye. A clear face shield was assessed ten times following a simulated cough using fluorescein dye. A conventional ultraviolet Woods lamp was compared to a smartphone-based cobalt blue light to detect fluorescein illumination. Results. The simulation platform and smartphone-based cobalt blue light cost $20.18. A Wilcoxon signed rank test revealed that the median droplet area of fluorescence under the UV Wood's lamp was not significantly different than that of the smartphone-based cobalt blue light (2.89 vs 2.94, P = .386). Conclusions. This simulation model is inexpensive and easily reproducible. The smartphone application may be a convenient alternative to standard ultraviolet lights. This model has great potential for use in financially restricted academic centers during the COVID-19 pandemic and beyond.

3D Printed Cobalt-Chromium-Molybdenum Porous Superalloy with Superior Antiviral Activity.

COVID-19 pandemic and associated supply-chain disruptions emphasise the requirement for antimicrobial materials for on-demand manufacturing. Besides aerosol transmission, SARS-CoV-2 is also propagated through contact with virus-contaminated surfaces. As such, the development of effective biofunctional materials that can inactivate SARS-CoV-2 is critical for pandemic preparedness. Such materials will enable the rational development of antiviral devices with prolonged serviceability, reducing the environmental burden of disposable alternatives. This research reveals the novel use of Laser Powder Bed Fusion (LPBF) to 3D print porous Cobalt-Chromium-Molybdenum (Co-Cr-Mo) superalloy with potent antiviral activity (100% viral inactivation in 30 min). The porous material was rationally conceived using a multi-objective surrogate model featuring track thickness (tt) and pore diameter (ϕd) as responses. The regression analysis found the most significant parameters for Co-Cr-Mo track formation to be the interaction effects of scanning rate (Vs) and laser power (Pl) in the order PlVs>Vs>Pl. Contrastively, the pore diameter was found to be primarily driven by the hatch spacing (Sh). The study is the first to demonstrate the superior antiviral properties of 3D printed Co-Cr-Mo superalloy against an enveloped virus used as biosafe viral model of SARS-CoV-2. The material significantly outperforms the viral inactivation time of other broadly used antiviral metals such as copper and silver, as the material's viral inactivation time was from 5 h to 30 min. As such, the study goes beyond the current state-of-the-art in antiviral alloys to provide extra protection to combat the SARS-CoV-2 viral spread. The evolving nature of the COVID-19 pandemic brings new and unpredictable challenges where on-demand 3D printing of antiviral materials can achieve rapid solutions while reducing the environmental impact of disposable devices.